IDENTIFICATION OF POTENTIAL SMALL MOLECULE ALLOSTERIC MODULATOR SITES ON IL-1R1 ECTODOMAIN USING ACCELERATED CONFORMATIONAL SAMPLING METHOD.

Identification of potential small molecule allosteric modulator sites on IL-1R1 ectodomain using accelerated conformational sampling method.

The interleukin-1 receptor (IL-1R) is the founding member of the interleukin 1 receptor family which activates innate immune response by its binding to cytokines.Reports showed dysregulation of cytokine production leads to aberrant immune cells activation which contributes to auto-inflammatory disorders and diseases.Current therapeutic strategies f

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PENGARUH KEPUTUSAN INVESTASI, KEPUTUSAN PENDANAAN DAN KEBIJAKAN DIVIDEN TERHADAP NILAI PERUSAHAAN FOOD AND BEVERAGES

Perusahaan yang inginmemaksimalkan nilai perusahaan,akan mengambil beberapa keputusan diantaranya keputusan investasi, kebijakan dividen, serta keputusan pendanaan.Tujuan penelitian ini adalah untuk menjelaskan pengaruh keputusan investasi, wella color touch 77 45 keputusan pendanaan, dan kebijakan dividen terhadap nilai perusahaan food and beverag

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Integrated Geoelectrical and Geological Investigation of a Quaternary Paleo-Depositional Environment in the Haripur Basin, Northern Pakistan: Implications for Groundwater System

The deposition in Haripur basin not only provides a contemporary insight into old fluvial depositional sequences of the 1073spx Himalayan foreland but also sheds light on the important continental depositions in a monsoon controlled foreland system.The present study emphasizes the evaluation of the paleo-depositional architecture for sustainable gr

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Autonomous control system road construction machine

The increasing requirements for the accuracy of construction work lead to the need to create modern control systems that will eliminate the human operator from the process of controlling road construction machines, increase the energy efficiency and productivity of these machines, as well as the quality of the finished construction object.The use o

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